Now showing items 1-20 of 22

    • Pérez, Paola; Aguilera, Sergio; Olea, Nancy; Alliende, Cecilia; Molina, Claudio; Brito, Mónica; Barrera, María José; Leyton Martínez, Cecilia; Rowzee, Anne; González Burgos, María Julieta (2010)
      Objectives. To analyse whether the alterations in the structure and organization of microvilli in salivary acinar cells from SS patients are linked to changes in the expression and/or cellular localization of ezrin. Methods. ...
    • González, Sergio; Aguilera, Sergio; Alliende, Cecilia; Urzúa Tobar, Ulises; Quest, Andrew F. G.; Herrera Cisterna, Luisa; Molina, Claudio; Hermoso Ramello, Marcela; Ewert, Patricia; Brito, Mónica; Romo, Rafael; Leyton Martínez, Cecilia; Pérez, Paola; González Burgos, María Julieta (2011-04)
      Objective. Acinar cells in the salivary glands of patients with Sjo¨gren’s syndrome (SS) display severe alterations in anchorage to the basal lamina. Bioinformatics analysis of the BP230 gene sequence has revealed the ...
    • González Burgos, María Julieta; Galanti Garrone, Norbel; López Solís, Remigio (1989)
      The presence, distribution and content of sialic acid on the cell surface in collagenase-dispersed acini obtained both from unstimulated as well as from in vivo isoproterenol-stimulated mouse parotid have been studied. To ...
    • Fuente, Marjorie de la; Franchi, Luigi; Araya, Daniela; Díaz Jiménez, David; Olivares, Mauricio; Álvarez Lobos, Manuel; Golenbock, Douglas; González Burgos, María Julieta; López Kostner, Francisco; Quera Pino, Rodrigo; Núñez, Gabriel; Vidal Álvarez, Roberto; Hermoso Ramello, Marcela (ELSEVIER, 2015)
    • Galindo, Mario A.; González Burgos, María Julieta; Galanti Garrone, Norbel (Society of Biology of Chile, 2002)
      Echinococcus granulosus is a parasitic platyhelminth that is responsible for cystic hydatid disease. From the inner, germinal layer of hydatid cysts protoscoleces are generated, which are are the infective forms to the ...
    • Lagos Alfaro, Carolina Andrea (Universidad de Chile, 2017)
      El síndrome de Sjögren (SS) es una enfermedad autoinmune, inflamatoria, crónica y sistémica, de etiología desconocida y afecta principalmente a glándulas salivales y lagrimales. Se ha estudiado la respuesta a proteínas mal ...
    • Carvajal Garcés, Patricia Alejandra (Universidad de Chile, 2017)
      síndrome de Sjögren (SS) es una exocrinopatía autoinmune crónica, inflamatoria y sistémica que afecta principalmente a las glándulas salivales (GS) y lagrimales. Resultados de nuestro laboratorio demuestran que las células ...
    • Fuente, Marjorie de la; Franchi, Luigi; Araya, Daniela; Díaz Jiménez, David; Olivares, Mauricio; Álvarez Lobos, Manuel; Golenbock, Douglas; González Burgos, María Julieta; López Kostner, Francisco; Quera Pino, Rodrigo; Núñez, Gabriela; Vidal Álvarez, Roberto; Hermoso Ramello, Marcela (Elsevier, 2014)
      Crohn’s disease (CD) is a multifactorial pathology associated with the presence of adherent-invasiveEscherichia coli (AIEC) and NLRP3 polymorphic variants. The presence of intracellular E. coli in otherintestinal pathologies ...
    • Cortés Troncoso, Juan (Universidad de Chile, 2016)
      El Síndrome de Sjögren (SS) es una enfermedad autoinmune sistémica, que afecta a las glándulas exocrinas, principalmente a las glándulas salivales y lagrimales, generando en los pacientes síntomas de sequedad bucal y ...
    • Ewert Medina, Patricia (Universidad de Chile, 2006)
      El síndrome de Sjögren (SS) es una enfermedad inflamatoria, autoinmune, crónica de etiología desconocida, que compromete esencialmente a las glándulas salivales y lagrimales, generando xeroftalmia (sequedad ocular) y ...
    • Olivares Morales, Mauricio; Fuente, Marjorie de la; Dubois Camacho, Karen; Palominos Parada, Daniela Paz; Díaz Jiménez, David; Torres Riquelme, Alejandro; Xu, Xiaojiang; Chamorro Veloso, Nayaret; Naves, Rodrigo; González Burgos, María Julieta; Quera Pino, Rodrigo; Figueroa, Carolina; Cidlowski, John Anthony; Vidal, Roberto; Hermoso Ramello, Marcela (Frontiers Media, 2018)
      Crohn's disease (CD) is a chronic inflammatory bowel disorder characterized by deregulated inflammation triggered by environmental factors Notably, adherent-invasive Escherichia coli (AIEC), a bacterium with the ability ...
    • Pérez, Paola; Kwon, Yoon-Jeoung; Alliende, Cecilia; Leyton Campos, Lisette; Aguilera, Sergio; Molina, Claudio; Labra, Cecilia; Julio, Marcelo; Leyton Martínez, Cecilia; González Burgos, María Julieta (WILEY-LISS, DIV JOHN WILEY & SONS INC, 2005-09)
      Objective. Previous findings in labial salivary glands (LSGs) from patients with Sjogren ' s syndrome (SS) suggest that increased activity and expression of matrix metalloproteinase 9 (MMP-9) and MMP-3 trigger the destruction ...
    • Candia, Enzo; Díaz Jiménez, David; Langjahr, Patricia; Núñez, Lucía E.; Fuente, Marjorie de la; Farfán, Nancy; López Kostner, Francisco; Abedrapo Moreira, Mario Antonio; Alvarez Lobos, Manuel; Pinedo, George; Beltrán, Caroll J.; González, Carlos; González Burgos, María Julieta; Quera Pino, Rodrigo (2012)
      Toll-like receptor 2 (TLR2) is a type I pattern recognition receptor that has been shown to participate in intestinal homeostasis. Its increased expression in the lamina propria has been associated with the pathogenesis ...
    • Velozo Hermosilla, José (Universidad de Chile, 2006)
      El síndrome de Sjögren es una enfermedad autoinmune que causa alteraciones en la estructura y función de las glándulas exocrinas debido a la destrucción de la lámina basal de acinos y ductos, y a la degradación de las ...
    • Paez, Maria Carolina; González Burgos, María Julieta; Serrano, Norma C.; Shoenfeld, Yehuda; Anaya, Juan Manuel (TAYLOR & FRANCIS LTD, 2007-03)
      The extracellular matrix plays an important role in modulating the behavior of cells with which it interacts. There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and ...
    • Barrera, María José; Aguilera, Sergio; Castro, Isabel; Cortés Araya, Juan Eliecer; Bahamondes Lorca, Verónica; Quest, Andrew F. G.; Molina, Claudio; González, Sergio; Hermoso Ramello, Marcela; Urzúa Tobar, Ulises; Leyton, Cecilia; González Burgos, María Julieta (Elsevier, 2016)
      Salivary gland (SG) acinar-cells are susceptible to endoplasmic reticulum (ER) stress related to their secretory activity and the complexity of synthesized secretory products. SGs of Sji5gren's syndrome patients (SS)-patients ...
    • Landskron Ramos, Glauben Tamara; Dubois Camacho, Karen; Orellana Serradell, Octavio Andrés; Fuente López, Majorie de la; Parada Venegas, Daniela Estefani; Bitrán Ambler, Mirit Luisa; Díaz Jiménez, David; Tang, Shuang; Cidlowski, John A.; Li, Xiaoling; Molina, Héctor; González, Carlos M.; Simian, Daniela; Lubascher, Jaime; Pola, Víctor; Montecino, Martín; Blokzijl, Tjasso; Faber, Klaas Nico; González Burgos, María Julieta; Quera, Rodrigo; Hermoso, Marcela Alejandra (MDPI, 2022)
      Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) and can be treated with glucocorticoids (GC), although some patients are unresponsive to this therapy. The transcription factor LRH-1/NR5A2 is critical to ...
    • Barrera, María José; Aguilera, Sergio; Veerman, Enno; Quest, Andrew F. G.; Díaz Jiménez, David; Urzúa Tobar, Ulises; Cortés Araya, Juan Eliecer; González, Sergio; Castro, Isabel; Molina, Claudio; Bahamondes, Verónica; Leyton, Cecilia; Hermoso Ramello, Marcela; González Burgos, María Julieta (Oxford Univ Press, 2015)
      Objectives. A hallmark characteristic of SS patients is the ectopic presence of the mucins MUC5B and MUC7 in the extracellular matrix of salivary glands that have lost apical basolateral acinar-cell polarity. This study ...
    • Castro Masso, Isabel Verónica; Carvajal Garcés, Patricia Alejandra; Jara, Daniela; Aguilera, Sergio; Heathcote Pérez, Benjamín Norman; Barrera, María José; Aliaga Tobar, Víctor Manuel; Maracaja Coutinho, Vinicius; Urzúa Tobar, Ulises; Quest, Andrew Frederick Geoffery; González, Sergio; Claudio, Molina; Hermoso, Marcela Alejandra; González Burgos, María Julieta (Frontiers Media, 2022)
      MicroRNAs (miRNAs) are small non-coding RNAs (sRNA), that alter gene expression by binding to target messenger RNAs (mRNAs) and repressing translation. Dysregulated miRNA expression has been implicated in the pathogenesis ...